ALDOLASE

Aldolase is an enzyme involved in glucose (energy) metabolism. It helps break down sugars during glycolysis to produce energy.

It is found mainly in:

• Skeletal muscles

• Liver

• Heart

• Brain

🔬 What Aldolase Does

In glycolysis:
Fructose-1,6-bisphosphate → (via aldolase) →

• Glyceraldehyde-3-phosphate

• Dihydroxyacetone phosphate

This step helps cells produce energy (ATP).

🩺 Why Doctors Order an Aldolase Test

It is mainly used to evaluate muscle damage or muscle disease, such as:

• Polymyositis

• Dermatomyositis

• Muscular dystrophy

• Unexplained muscle weakness

It may also be elevated in liver disease.

📊 Normal Range

• Typically 1.0 – 7.5 U/L
  (Ranges vary by laboratory.)

🚨 High Aldolase Levels May Indicate

• Muscle inflammation

• Muscle injury

• Liver damage

• Certain metabolic disorders

📝 Key Points

• Often tested along with CK (Creatine Kinase).

• Elevated levels suggest muscle cell damage.

• Not commonly used alone for diagnosis.